Quantitative Analyses of Circadian Gene Expression in Mammalian Cell Cultures

Open Access

Peer-reviewed

Research Article

Mariko Izumo,

¤ Current address: Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America

Affiliation Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America
⨯
Takashi R Sato,

Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
⨯
Martin Straume,

Affiliation Customized Online Biomathematical Research Applications, Charlottesville, Virginia, United States of America
⨯
Carl Hirschie Johnson

*To whom correspondence should be addressed. E-mail: carl.h.johnson@vanderbilt.edu

Affiliation Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America
⨯

Reader Comments

For a more detailed description of our method of quantitative analysis as well as a brief description of the software analysis package included with the LumiCycle, please see
http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020136#article1.body1.sec4.sec4.p4

Similar methodology may be found at: http://millar.bio.ed.ac.uk/PEBrown/BRASS/BrassPage.htm

No competing interests declared.

Circadian oscillators
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Genetic oscillators
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Circadian rhythms
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Fibroblasts
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Cell cultures
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Drug therapy
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Gene expression
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Luminescence
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