The Landscape of the Prion Protein's Structural Response to Mutation Revealed by Principal Component Analysis of Multiple NMR Ensembles

Deena M. A. Gendoo; Paul M. Harrison

doi:10.1371/journal.pcbi.1002646

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Open Access

Peer-reviewed

Research Article

The Landscape of the Prion Protein's Structural Response to Mutation Revealed by Principal Component Analysis of Multiple NMR Ensembles

Deena M. A. Gendoo,

Affiliations Department of Biology, McGill University, Montreal, Quebec, Canada, McGill Center for Bioinformatics, McGill University, Montreal, Quebec, Canada
⨯
Paul M. Harrison

* E-mail: paul.harrison@mcgill.ca

Affiliations Department of Biology, McGill University, Montreal, Quebec, Canada, McGill Center for Bioinformatics, McGill University, Montreal, Quebec, Canada
⨯

The Landscape of the Prion Protein's Structural Response to Mutation Revealed by Principal Component Analysis of Multiple NMR Ensembles

Deena M. A. Gendoo,
Paul M. Harrison

Published: August 9, 2012
https://doi.org/10.1371/journal.pcbi.1002646

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Publisher's Note: Correction

Posted by harrisonpm7 on 13 Sep 2013 at 19:57 GMT

The text at the end of the Discussion section entitled "The Structural Response to Pathogenic Mutation",
beginning "Additionally, the S2-H2 loop...", and ending "transmissibility studies [10,15]", is incorrect and
should be replaced with:
"Additionally, the S2-H2 loop has been observed to exhibit varying levels of flexibility within TSE-non-susceptible species, and tends to be more rigid in TSE-susceptible species, making it a prime candidate for PrP transmissibility
studies [10,15]."

No competing interests declared.

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The Landscape of the Prion Protein's Structural Response to Mutation Revealed by Principal Component Analysis of Multiple NMR Ensembles

The Landscape of the Prion Protein's Structural Response to Mutation Revealed by Principal Component Analysis of Multiple NMR Ensembles

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Publisher's Note: Correction

Posted by harrisonpm7 on 13 Sep 2013 at 19:57 GMT