Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Dmitry Nevozhay; Rhys M. Adams; Elizabeth Van Itallie; Matthew R. Bennett; Gábor Balázsi

doi:10.1371/journal.pcbi.1002480

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Peer-reviewed

Research Article

Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Dmitry Nevozhay ,

Contributed equally to this work with: Dmitry Nevozhay, Rhys M. Adams

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Rhys M. Adams ,

Contributed equally to this work with: Dmitry Nevozhay, Rhys M. Adams

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Elizabeth Van Itallie,

Affiliation Department of Biochemistry and Cell Biology and Institute of Biosciences and Bioengineering, Rice University, Houston, Texas, United States of America
⨯
Matthew R. Bennett,

Affiliation Department of Biochemistry and Cell Biology and Institute of Biosciences and Bioengineering, Rice University, Houston, Texas, United States of America
⨯
Gábor Balázsi

* E-mail: gbalazsi@mdanderson.org

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Dmitry Nevozhay,
Rhys M. Adams,
Elizabeth Van Itallie,
Matthew R. Bennett,
Gábor Balázsi

Published: April 12, 2012
https://doi.org/10.1371/journal.pcbi.1002480

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Publisher's Note: Error in Results

Posted by PLOS_CompBiol on 11 Dec 2012 at 16:49 GMT

We quantified this by the subpopulation ratio R (Fig. 2D), defined as the number of cells with high yEGFP::zeoR expression divided by the number of cells with low yEGFP::zeoR expression.
http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002480#article1.body1.sec2.sec1.p3

There is an error in the third paragraph of the Results section in the definition of the subpopulation ratio R. The correct sentence is: “We quantified this by the subpopulation ratio R (Fig. 2D), defined as the number of cells with low yEGFP::zeoR expression divided by the number of cells with high yEGFP::zeoR expression.”

No competing interests declared.

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Gene expression
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Cell cycle and cell division
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Synthetic genetic networks
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Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

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Publisher's Note: Error in Results

Posted by PLOS_CompBiol on 11 Dec 2012 at 16:49 GMT