Natural Selection Fails to Optimize Mutation Rates for Long-Term Adaptation on Rugged Fitness Landscapes

• Jeff Clune ,

  * E-mail: jclune@msu.edu

  Affiliations Department of Computer Science and Engineering, Michigan State University, East Lansing, Michigan, United States of America, Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de València, València, Spain

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• Dusan Misevic,

  Affiliation Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland

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• Charles Ofria,

  Affiliation Department of Computer Science and Engineering, Michigan State University, East Lansing, Michigan, United States of America

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• Richard E. Lenski,

  Affiliation Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America

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• Santiago F. Elena,

  Affiliations Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de València, València, Spain, The Santa Fe Institute, Santa Fe, New Mexico, United States of America

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• Rafael Sanjuán

  Affiliations Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de València, València, Spain, Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València, València, Spain

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