The Evolutionary Dynamics of a Rapidly Mutating Virus within and between Hosts: The Case of Hepatitis C Virus

Fabio Luciani; Samuel Alizon

doi:10.1371/journal.pcbi.1000565

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Research Article

The Evolutionary Dynamics of a Rapidly Mutating Virus within and between Hosts: The Case of Hepatitis C Virus

Fabio Luciani ,

Contributed equally to this work with: Fabio Luciani, Samuel Alizon

* E-mail: luciani@unsw.edu.au (FL); samuel.alizon@env.ethz.ch (SA)

Affiliation Centre for Infection and Inflammation Research (CIIR), School of Medical Sciences, University of New South Wales, Sydney, Australia
⨯
Samuel Alizon

Contributed equally to this work with: Fabio Luciani, Samuel Alizon

* E-mail: luciani@unsw.edu.au (FL); samuel.alizon@env.ethz.ch (SA)

Affiliation Institut für Integrative Biologie, ETH, Zürich, Switzerland
⨯

The Evolutionary Dynamics of a Rapidly Mutating Virus within and between Hosts: The Case of Hepatitis C Virus

Fabio Luciani,
Samuel Alizon

Published: November 13, 2009
https://doi.org/10.1371/journal.pcbi.1000565

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reference omitted about the timing of treatment

Posted by alizon on 29 Nov 2009 at 17:07 GMT

We just realised that Ruy Ribeiro and Sebastian Bonhoeffer published an article in 1999 in AIDS, where they study the importance of the timing of treatment for HIV. Ribeiro and Bonhoeffer use a target cell limited model but reach a conclusion similar to us (treatment should be not be given too early to minimise the evolution of drug resistance).

Ribeiro, R.M. & Bonhoeffer, S. 1999. A stochastic model for primary hiv infection: optimal timing of therapy. AIDS 13: 351–7.

No competing interests declared.

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The Evolutionary Dynamics of a Rapidly Mutating Virus within and between Hosts: The Case of Hepatitis C Virus

The Evolutionary Dynamics of a Rapidly Mutating Virus within and between Hosts: The Case of Hepatitis C Virus

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reference omitted about the timing of treatment

Posted by alizon on 29 Nov 2009 at 17:07 GMT