Reader Comments
Post a new comment on this article
Post Your Discussion Comment
Please follow our guidelines for comments and review our competing interests policy. Comments that do not conform to our guidelines will be promptly removed and the user account disabled. The following must be avoided:
- Remarks that could be interpreted as allegations of misconduct
- Unsupported assertions or statements
- Inflammatory or insulting language
Thank You!
Thank you for taking the time to flag this posting; we review flagged postings on a regular basis.
closeOne spiking model reproducing varying activity
Posted by SOVF on 20 Sep 2010 at 05:44 GMT
These systematically varying, persistent temporal firing profiles are similar to those observed experimentally in vivo in frontal cortex during the delay period of the WM task [1], [3], [38], [39], but no previous spiking model of WM could reproduce them.
http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000879#article1.body1.sec2.sec4.p1
The authors claim that no spiking model could reproduce the systematically varying, persistent firing profiles as observed in frontal cortex. It seems they were unaware of this paper:
Verduzco-Flores S, Bodner M, Ermentrout B, Fuster JM, Zhou Y (2009) Working Memory Cells' Behavior May Be Explained by Cross-Regional Networks with Synaptic Facilitation. PLoS ONE 4(8): e6399. doi:10.1371/journal.pone.0006399
Link:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006399
The cited paper reproduces the delay period firing patterns reported in the following, rather extensive study:
Shafi M, Zhou Y, Quintana J, Chow C, Fuster J, Bodner M (2007) Variability in neuronal activity in primate cortex during working memory tasks. Neuroscience 146: 1082–1106.