Advertisement
Research Article

Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells

  • John C. Panetta mail,

    carl.panetta@stjude.org

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Alex Sparreboom,

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Ching-Hon Pui,

    Affiliations: Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Mary V. Relling,

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • William E. Evans

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Published: December 02, 2010
  • DOI: 10.1371/journal.pcbi.1001019

Reader Comments (1)

Post a new comment on this article

Publisher's Note: Error in Figure 7

Posted by PLoS_CompBiol on 16 Dec 2010 at 12:36 GMT

Simulations of the effects of lineage and dosage on model estimated DNPS activity.
http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1001019#pcbi-1001019-g007

In Figure 7 there is an error in the y-axis label. The correct label is “DNPS (% change of baseline)”.
Please see the corrected Figure 7 here: http://www.ploscompbiol.org/corrections/pcbi.1001019.g007.cn.tif

No competing interests declared.