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Transcription and disorder/low complexity features

Posted by PLOS_CompBiol on 26 Feb 2008 at 14:25 GMT

Originally submitted as a Reader Response on 3rd September 2007

It's very interesting to see the strong correlation between disorder and functions related to transcription and its control. This was also the strongest signal in <a href="http://www.biomedcentral....">Automatic discovery of cross-family sequence features associated with protein function</a>, where we found that a (presumably disordered) glutamine-rich feature was most strongly associated with transcription. Given these new results and the benefit of hindsight, we should have masked out the ordered regions and run the motif discovery again.

Submitted by: Bob MacCallum
E-mail: r.maccallum@imperial.ac.uk
Occupation: Staff Scientist
Imperial College London