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Research Article

Spatial and Topological Organization of DNA Chains Induced by Gene Co-localization

  • Ivan Junier,

    Affiliations: Epigenomics Project, Genopole, CNRS UPS 3201, UniverSud Paris, University of Evry, Genopole Campus 1 - Genavenir 6, Evry, France, Institut des Systèmes Complexes Paris Île-de-France, Paris, France

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  • Olivier Martin equal contributor,

    equal contributor Contributed equally to this work with: Olivier Martin, François Képès

    Affiliations: Université Paris-Sud, UMR 8626 LPTMS, F-91405, Orsay, France, Université Paris-Sud, UMR 0320/UMR 8120 Génétique Végétale, Gif/Yvette, France

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  • François Képès equal contributor mail

    equal contributor Contributed equally to this work with: Olivier Martin, François Képès

    francois.kepes@epigenomique.genopole.fr

    Affiliation: Epigenomics Project, Genopole, CNRS UPS 3201, UniverSud Paris, University of Evry, Genopole Campus 1 - Genavenir 6, Evry, France

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  • Published: February 12, 2010
  • DOI: 10.1371/journal.pcbi.1000678

Reader Comments (2)

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Nex experimental evidence in support of our approach

Posted by ivandespneus on 18 Feb 2010 at 10:13 GMT

Our work suggests the formation of specialized transcription factories to be a self-organized process driven by the bridging of distal co-regulated genes via the binding of transcription factors. The binding can be direct (bivalent transcription factors) or can involve intermediate large protein complexes, such as the transcription factories themselves.

In this respect, the experimental results recently published in the article "Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells" by Schoenfelder et al. in Nature Genetics, 42, 53-61 (2010) give fresh evidence for the relevance of our approach.

The authors

No competing interests declared.