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Research Article

Phylogenetic and Functional Assessment of Orthologs Inference Projects and Methods

  • Adrian M. Altenhoff mail,

    adrian.altenhoff@inf.ethz.ch

    Affiliation: Institute of Computational Science, ETH Zurich, and Swiss Institute of Bioinformatics, Zürich, Switzerland

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  • Christophe Dessimoz

    Affiliation: Institute of Computational Science, ETH Zurich, and Swiss Institute of Bioinformatics, Zürich, Switzerland

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  • Published: January 16, 2009
  • DOI: 10.1371/journal.pcbi.1000262

Reader Comments (1)

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Orthology

Posted by JLBoore on 03 Feb 2009 at 22:38 GMT

Orthology is the relationship of two or more genes as a result of speciation. All other uses of the term are wrong, including those based on conserved function or conserved gene position after rearrangement. Each of these factors, along with patterns of sequence similarity, is material to the determination of whether genes are orthologous, but is not an alternative definition.

This is far beyond a semantic issue. The muddled use of this term has resulted in a great deal of illogical nonsense being published. Frankly, I'm bewildered that more of that is not eliminated by peer review. (None of this is a criticism of this article, except perhaps that it presents these alternative definitions without the negative critique that they merit.)