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Research Article

The Evolutionary Dynamics of a Rapidly Mutating Virus within and between Hosts: The Case of Hepatitis C Virus

  • Fabio Luciani equal contributor mail,

    equal contributor Contributed equally to this work with: Fabio Luciani, Samuel Alizon

    luciani@unsw.edu.au (FL); samuel.alizon@env.ethz.ch (SA)

    Affiliation: Centre for Infection and Inflammation Research (CIIR), School of Medical Sciences, University of New South Wales, Sydney, Australia

    X
  • Samuel Alizon equal contributor mail

    equal contributor Contributed equally to this work with: Fabio Luciani, Samuel Alizon

    luciani@unsw.edu.au (FL); samuel.alizon@env.ethz.ch (SA)

    Affiliation: Institut für Integrative Biologie, ETH, Zürich, Switzerland

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  • Published: November 13, 2009
  • DOI: 10.1371/journal.pcbi.1000565

Reader Comments (1)

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reference omitted about the timing of treatment

Posted by alizon on 29 Nov 2009 at 17:07 GMT

We just realised that Ruy Ribeiro and Sebastian Bonhoeffer published an article in 1999 in AIDS, where they study the importance of the timing of treatment for HIV. Ribeiro and Bonhoeffer use a target cell limited model but reach a conclusion similar to us (treatment should be not be given too early to minimise the evolution of drug resistance).


Ribeiro, R.M. & Bonhoeffer, S. 1999. A stochastic model for primary hiv infection: optimal timing of therapy. AIDS 13: 351–7.

No competing interests declared.