A beautiful piece we have here. This top-down approach will turn to be a test site for our insight into lipidic metabolism and will eventually help bursting research in this field, attracting interest by researchers focused on other fields also (just as the availability of HOMA did for glucose metabolism).
I'd like to see the model tested on specific questions, soon. If I could suggest one, I'd like to talk about CETP inhibitors, arguing that an instrument like this one would have helped/would help districating ourselves in the insidious issue of what the meaning would be of a "higher" HDLcholestorelemia -> Cardiovasc Ther. 2008 ;26 (2):135-46