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Research Article

Dose-to-Duration Encoding and Signaling beyond Saturation in Intracellular Signaling Networks

  • Marcelo Behar,

    Affiliations: Department of Physics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America, Program in Cellular and Molecular Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Nan Hao,

    Affiliation: Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Henrik G. Dohlman,

    Affiliations: Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Timothy C. Elston mail

    telston@med.unc.edu

    Affiliation: Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: October 10, 2008
  • DOI: 10.1371/journal.pcbi.1000197

Reader Comments (1)

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Simulations might also apply to PC12 cells....

Posted by Bossi on 16 Oct 2008 at 21:28 GMT

....where EGF and insulin receptor overexpression switches MAPK signalling from transient to sustained.

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation.
Curr Biol. 1994 Aug 1;4(8):702-8.

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor.
Curr Biol. 1994 Aug 1;4(8):694-701.