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Research Article

Identifying Causal Genes and Dysregulated Pathways in Complex Diseases

  • Yoo-Ah Kim,

    Affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Stefan Wuchty,

    Affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Teresa M. Przytycka mail

    przytyck@ncbi.nlm.nih.gov

    Affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: March 03, 2011
  • DOI: 10.1371/journal.pcbi.1001095

Reader Comments (1)

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Complex diseases and the cat

Posted by phidalgo on 10 Mar 2011 at 20:44 GMT

Sometimes I feel we are in the dark room with the cat and do not know where it is or if he is dead. Complex diseases are still a subject of debate and analysis but the genotype phenotype relationship is not established. Despite the efforts and dozens of publications we still have a basis on how to operate the additive effects of genes maybe the answer is in the interaction at the level of pathways and metabolites. The article by Kim et al. indicates this possibility, but we must expect more experimental evidence. PC Hidalgo.

No competing interests declared.