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The Rough Guide to In Silico Function Prediction, or How To Use Sequence and Structure Information To Predict Protein Function

  • Marco Punta,

    Affiliations: Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America, Columbia University Center for Computational Biology and Bioinformatics (C2B2), New York, New York, United States of America, Northeast Structural Genomics Consortium (NESG), Columbia University, New York, New York, United States of America

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  • Yanay Ofran mail

    yanay@ofranlab.org

    Affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

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  • Published: October 31, 2008
  • DOI: 10.1371/journal.pcbi.1000160
  • Featured in PLOS Collections

Reader Comments (1)

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Important problem

Posted by klager on 10 Nov 2008 at 10:48 GMT

This concerns an important problem. With the speed of the new large scale techniques, annotations is often done automatically, with disastrous result. The article is missing some areas that are very useful for annotation, that includes all the new text mining tools. The sequence and structure databases, are way behind the experimental data found in the ~20 million articles available.