Affiliation
University of Leeds, Leeds Institute of Molecular Medicine Section of Experimental Therapeutics, St. James's University Hospital, Leeds, United Kingdom
Affiliation
Department of Systems and Computational Biology, Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America
Affiliation
Department of Systems and Computational Biology, Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America
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Idea
Posted by Balli2010
on
08 Oct 2011 at 22:24 GMT
We explored the frequency of occurrences of an exhaustively classified library of supersecondary structural elements (Smotifs), in protein structures, in order to identify features that would define a fold as novel compared to previously known structures. We found that a surprisingly small set of Smotifs is sufficient to describe all known folds. Furthermore, novel folds do not require novel Smotifs, but rather are a new combination of existing ones. http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000750#article1.front1.article-meta1.abstract1.p1
