High Epitope Expression Levels Increase Competition between T Cells

Almut Scherer; Marcel Salathé; Sebastian Bonhoeffer

doi:10.1371/journal.pcbi.0020109

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Open Access

Peer-reviewed

Research Article

High Epitope Expression Levels Increase Competition between T Cells

Almut Scherer,

Affiliation Theoretical Biology, Institute of Integrative Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
⨯
Marcel Salathé,

Affiliation Theoretical Biology, Institute of Integrative Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
⨯
Sebastian Bonhoeffer

*To whom correspondence should be addressed. E-mail: seb@env.ethz.ch

Affiliation Theoretical Biology, Institute of Integrative Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
⨯

High Epitope Expression Levels Increase Competition between T Cells

Almut Scherer,
Marcel Salathé,
Sebastian Bonhoeffer

Published: August 18, 2006
https://doi.org/10.1371/journal.pcbi.0020109

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T-cell populations do parallel processing

Posted by czkmt on 18 Jun 2009 at 11:38 GMT

This article sheds lights on a mechanism underlying efficacious and cost-effective immune surveillance, especially when limited amount of antigen is available for recognition by T-cells. The authors' ideas will give insights into determinants for malignancies and persistent viral infections.

No competing interests declared.

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T cells
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Antigen-presenting cells
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Immune response
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Cell binding
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High Epitope Expression Levels Increase Competition between T Cells

High Epitope Expression Levels Increase Competition between T Cells

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T-cell populations do parallel processing

Posted by czkmt on 18 Jun 2009 at 11:38 GMT