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closePublisher's Note: Errors in Equations
Posted by PLOS_CompBiol on 08 Aug 2013 at 13:56 GMT
There are errors in the first and second equations of the section “History and Mathematical Formalisms”, subsection “The Hill Equation”. http://www.ploscompbiol.o...
The Hill equation should be read as:
Ybar=K.[X]^n/(1+K.[X]^n)=[X]^n/(K*+[X]^n)=[X]^n/(Kd^n+[X]^n)
where n is the "Hill coefficient", [X] denotes ligand concentration, K denotes an apparent association constant (used in the original form of the equation), K* is an apparent dissociation constant (equivalent to an EC50) and Kd a microscopic dissociation constant (used in modern forms of the equation).
The equation of the Hill plot should read as:
log(Ybar/(1-Ybar))=n.log[X]-n.logKd
RE: Publisher's Note: Errors in Equations
melaniestefan replied to PLOS_CompBiol on 05 May 2016 at 16:14 GMT
It is actually Kd that is equivalent to an EC50, not K*. We thank Prof. Ronald K. Gary, Ph.D. from the University of Nevada, Las Vegas, for spotting this.