Reader Comments
Post a new comment on this article
Post Your Discussion Comment
Please follow our guidelines for comments and review our competing interests policy. Comments that do not conform to our guidelines will be promptly removed and the user account disabled. The following must be avoided:
- Remarks that could be interpreted as allegations of misconduct
- Unsupported assertions or statements
- Inflammatory or insulting language
Thank You!
Thank you for taking the time to flag this posting; we review flagged postings on a regular basis.
closeRight-hand panel Figure 2B
Posted by JAryaman on 08 Dec 2013 at 11:13 GMT
Can we assume that the blue line in the right-hand panel of Figure 2B is low expression of hsa-miR-330-3p, and the green line is high expression, as is the convention in Figures S2 and S3? Therefore this graph has not been stratified according to your method?
If so, do these plots have fewer data points as you must neglect intermediate levels of expression of the gene or miR?
RE: Right-hand panel Figure 2B
Rotem_BenHamo replied to JAryaman on 02 Jan 2014 at 12:24 GMT
The blue and green lines are indeed according to your assumptions. The figure demonstrates the fact that hsa-miR-330-3p, by itself, and without the context of the gene MAF, does NOT carry any stratification features. These are the same numbers of patients as in the left hand side subfigure.
Supporting Figures S2 and S3 are there to further clarify this point. We used a different set of data for these figures. And, as the figures demonstrate, neither these miRs, nor these genes, by themselves, serve to stratify patients, yet the miR-gene pairs, do.