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Research Article

Aggregation Propensity of the Human Proteome

  • Elodie Monsellier equal contributor,

    equal contributor Contributed equally to this work with: Elodie Monsellier, Matteo Ramazzotti

    Affiliation: Dipartimento di Scienze Biochimiche, Università degli studi di Firenze, Florence, Italy

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  • Matteo Ramazzotti equal contributor,

    equal contributor Contributed equally to this work with: Elodie Monsellier, Matteo Ramazzotti

    Affiliation: Dipartimento di Scienze Biochimiche, Università degli studi di Firenze, Florence, Italy

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  • Niccolò Taddei,

    Affiliation: Dipartimento di Scienze Biochimiche, Università degli studi di Firenze, Florence, Italy

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  • Fabrizio Chiti mail

    fabrizio.chiti@unifi.it

    Affiliations: Dipartimento di Scienze Biochimiche, Università degli studi di Firenze, Florence, Italy, Consorzio interuniversitrio “Istituto Nazionale Biostrutture e Biosistemi” (I.N.B.B.), Rome, Italy

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  • Published: October 17, 2008
  • DOI: 10.1371/journal.pcbi.1000199

Reader Comments (1)

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Fine Modulation of Aggregation Propensity Adaptively Advantageous?

Posted by forsdyke on 31 Oct 2008 at 20:37 GMT

In an important paper, Monsellier and coauthors provide evidence that in the course of "molecular evolution" there has been "a negative selection pressure" acting on many "protein sequences to finely modulate their aggregation propensities depending on different parameters related to their in vivo environment." They rightly conclude that we must "learn the 'tricks' set up by Nature to effectively control protein aggregation in the highly crowded environments of living organisms." It is understandable that they should employ the word "control" is the sense of preventing something bad happening, since we currently associate many diseases with protein aggregation. However, a case has been made that there are also circumstances in which Nature has favored the tendency of proteins to aggregate. The propensity to aggregate could be adaptively advantageous. The fine modulation of this propensity could permit intracellular self/not-self discrimination. For details please see: http://post.queensu.ca/~f... and http://post.queensu.ca/~f...