Parameter Trajectory Analysis to Identify Treatment Effects of Pharmacological Interventions

Christian A. Tiemann; Joep Vanlier; Maaike H. Oosterveer; Albert K. Groen; Peter A. J. Hilbers; Natal A. W. van Riel

doi:10.1371/journal.pcbi.1003166

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Open Access

Peer-reviewed

Research Article

Parameter Trajectory Analysis to Identify Treatment Effects of Pharmacological Interventions

Christian A. Tiemann ,

* E-mail: c.a.tiemann@tue.nl

Affiliations Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands
⨯
Joep Vanlier,

Affiliations Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands
⨯
Maaike H. Oosterveer,

Affiliation Department of Pediatrics, University Groningen, University Medical Center Groningen, Groningen, The Netherlands
⨯
Albert K. Groen,

Affiliations Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands, Department of Pediatrics, University Groningen, University Medical Center Groningen, Groningen, The Netherlands, Department of Laboratory Medicine, University Groningen, University Medical Center Groningen, Groningen, The Netherlands
⨯
Peter A. J. Hilbers,

Affiliations Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands
⨯
Natal A. W. van Riel

Affiliations Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands
⨯

Parameter Trajectory Analysis to Identify Treatment Effects of Pharmacological Interventions

Christian A. Tiemann,
Joep Vanlier,
Maaike H. Oosterveer,
Albert K. Groen,
Peter A. J. Hilbers,
Natal A. W. van Riel

Published: August 1, 2013
https://doi.org/10.1371/journal.pcbi.1003166

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animation illustrating the ADAPT approach

Posted by nvriel on 12 Feb 2014 at 20:01 GMT

We have created an animation illustrating the modeling approach introduced in this paper. It is available on YouTube: http://www.youtube.com/wa...
ADAPT (Analysis of Dynamic Adaptations in Parameter Trajectories) is a modeling approach to simulate the progression of metabolic diseases.

/Natal van Riel

No competing interests declared.

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Parameter Trajectory Analysis to Identify Treatment Effects of Pharmacological Interventions

Parameter Trajectory Analysis to Identify Treatment Effects of Pharmacological Interventions

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animation illustrating the ADAPT approach

Posted by nvriel on 12 Feb 2014 at 20:01 GMT