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Posted by Balli2010 on 08 Oct 2011 at 22:25 GMT

We also demonstrated that the available set of Smotifs has been essentially unchanged at least for the last 5 years, despite that during this time the sequence databases have doubled and a significant number of new folds have emerged [23]
http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000750#article1.body1.sec1.p2

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