Advertisement
Research Article

Relating Neuronal Firing Patterns to Functional Differentiation of Cerebral Cortex

  • Shigeru Shinomoto equal contributor mail,

    equal contributor Contributed equally to this work with: Shigeru Shinomoto, Hideaki Kim, Takeaki Shimokawa

    shinomoto@scphys.kyoto-u.ac.jp

    Affiliation: Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan

    X
  • Hideaki Kim equal contributor,

    equal contributor Contributed equally to this work with: Shigeru Shinomoto, Hideaki Kim, Takeaki Shimokawa

    Affiliation: Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan

    X
  • Takeaki Shimokawa equal contributor,

    equal contributor Contributed equally to this work with: Shigeru Shinomoto, Hideaki Kim, Takeaki Shimokawa

    Affiliation: Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan

    X
  • Nanae Matsuno,

    Affiliation: Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan

    X
  • Shintaro Funahashi,

    Affiliation: Kokoro Research Center, Kyoto University, Sakyo-ku, Kyoto, Japan

    X
  • Keisetsu Shima,

    Affiliation: Department of Physiology, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan

    X
  • Ichiro Fujita,

    Affiliation: Laboratory for Cognitive Neuroscience, Graduate School of Frontier Biosciences, Osaka University, Toyonaka, Osaka, Japan

    X
  • Hiroshi Tamura,

    Affiliation: Laboratory for Cognitive Neuroscience, Graduate School of Frontier Biosciences, Osaka University, Toyonaka, Osaka, Japan

    X
  • Taijiro Doi,

    Affiliation: Laboratory for Cognitive Neuroscience, Graduate School of Frontier Biosciences, Osaka University, Toyonaka, Osaka, Japan

    X
  • Kenji Kawano,

    Affiliation: Department of Integrative Brain Science, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

    X
  • Naoko Inaba,

    Affiliation: Department of Integrative Brain Science, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

    X
  • Kikuro Fukushima,

    Affiliation: Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan

    X
  • Sergei Kurkin,

    Affiliation: Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan

    X
  • Kiyoshi Kurata,

    Affiliation: Department of Physiology, Hirosaki University School of Medicine, Hirosaki, Japan

    X
  • Masato Taira,

    Affiliation: Division of Applied System Neuroscience, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, Tokyo, Japan

    X
  • Ken-Ichiro Tsutsui,

    Affiliation: Division of Systems Neuroscience, Tohoku University Graduate School of Life Sciences, Aoba-ku, Sendai, Japan

    X
  • Hidehiko Komatsu,

    Affiliation: Division of Sensory and Cognitive Information, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan

    X
  • Tadashi Ogawa,

    Affiliations: Department of Integrative Brain Science, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan, Division of Sensory and Cognitive Information, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan

    X
  • Kowa Koida,

    Affiliation: Division of Sensory and Cognitive Information, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan

    X
  • Jun Tanji,

    Affiliation: Tamagawa University Brain Science Institute, Machida, Tokyo, Japan

    X
  • Keisuke Toyama

    Affiliation: ATR Computational Neuroscience Laboratories, Seika-cho, Soraku-gun, Kyoto, Japan

    X
  • Published: July 10, 2009
  • DOI: 10.1371/journal.pcbi.1000433

Reader Comments (2)

Post a new comment on this article

Amount of data required to compute the newly introduced metrics

Posted by rjolivet on 18 Aug 2009 at 15:35 GMT

Could the authors indicate how many ISIs are required in order to compute LvR or Lv with a fair precision?

No competing interests declared.

RE: Amount of data required to compute the newly introduced metrics

shino replied to rjolivet on 18 Aug 2009 at 23:52 GMT

In our paper, we required the number of spikes > 2000 for the purpose of examining the invariance of the firing irregularity in time, but the instantaneous irregularity can be estimated using fewer interspike-intervals (ISIs).

I may venture to say that the number of ISIs needed to obtain a reliable estimate of firing irregularity is from n=50 to 100: Because the local variation, LvR or Lv, is given as the arithmetic average of independent terms, the metric obeys the central limit theorem. Therefore, its standard deviation (SD) is expected to be of the order of sqrt{1/n}. For n=100, SD is expected to be about 0.1. It should be noted that the conventional coefficient of variation, Cv, is not given in the arithmetic average, and does not obey the central limit theorem, and therefore its SD turns out to be much larger, giving greater fluctuation.

No competing interests declared.