## Reader Comments (2)

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### Amount of data required to compute the newly introduced metrics

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Posted by rjolivet
on
**18 Aug 2009 **at** 15:35 GMT**

Could the authors indicate how many ISIs are required in order to compute LvR or Lv with a fair precision?

**No competing interests declared.**

### RE: Amount of data required to compute the newly introduced metrics

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shino
replied to
rjolivet
on
**18 Aug 2009 **at** 23:52 GMT**

In our paper, we required the number of spikes > 2000 for the purpose of examining the invariance of the firing irregularity in time, but the instantaneous irregularity can be estimated using fewer interspike-intervals (ISIs).

I may venture to say that the number of ISIs needed to obtain a reliable estimate of firing irregularity is from n=50 to 100: Because the local variation, LvR or Lv, is given as the arithmetic average of independent terms, the metric obeys the central limit theorem. Therefore, its standard deviation (SD) is expected to be of the order of sqrt{1/n}. For n=100, SD is expected to be about 0.1. It should be noted that the conventional coefficient of variation, Cv, is not given in the arithmetic average, and does not obey the central limit theorem, and therefore its SD turns out to be much larger, giving greater fluctuation.

**No competing interests declared.**

## Comments

Amount of data required to compute the newly introduced metrics

Posted by rjolivet

LvR for low frequency activity

Posted by Blowfish