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Review

From Structure Prediction to Genomic Screens for Novel Non-Coding RNAs

  • Jan Gorodkin mail,

    gorodkin@rth.dk (JG); ivo@tbi.univie.ac.at (ILH)

    Affiliations: Center for non-coding RNA in Technology and Health, IBHV University of Copenhagen, Frederiksberg, Denmark, Division of Genetics and Bioinformatics, IBHV University of Copenhagen, Frederiksberg, Denmark

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  • Ivo L. Hofacker mail

    gorodkin@rth.dk (JG); ivo@tbi.univie.ac.at (ILH)

    Affiliations: Center for non-coding RNA in Technology and Health, IBHV University of Copenhagen, Frederiksberg, Denmark, Department of Theoretical Chemistry, University of Vienna, Wien, Austria

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  • Published: August 04, 2011
  • DOI: 10.1371/journal.pcbi.1002100

Reader Comments (3)

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Citation & discussion missing

Posted by JPanek on 10 Aug 2011 at 12:32 GMT

Suboptimal structures have not yet been taken systematically into account in ncRNA gene finding methods. However, at least in some cases, they might be essential for the detection of functional RNAs.
http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002100#article1.body1.sec7.p7

A paper thoroughly dealing with the issue has been published ("The suboptimal structures find the optimal RNAs: homology search for bacterial non-coding RNAs using suboptimal RNA structures” by Pánek J, Krásny L, Bobek J, Jezková E, Korelusová J and Vohradsky J., Nucleic Acids Res. 2011 Apr;39(8):3418-26. Epub 2010 Dec 30.).

No competing interests declared.