From Structure Prediction to Genomic Screens for Novel Non-Coding RNAs

Jan Gorodkin; Ivo L. Hofacker

doi:10.1371/journal.pcbi.1002100

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From Structure Prediction to Genomic Screens for Novel Non-Coding RNAs

Jan Gorodkin ,

* E-mail: gorodkin@rth.dk (JG); ivo@tbi.univie.ac.at (ILH)

Affiliations Center for non-coding RNA in Technology and Health, IBHV University of Copenhagen, Frederiksberg, Denmark, Division of Genetics and Bioinformatics, IBHV University of Copenhagen, Frederiksberg, Denmark
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Ivo L. Hofacker

* E-mail: gorodkin@rth.dk (JG); ivo@tbi.univie.ac.at (ILH)

Affiliations Center for non-coding RNA in Technology and Health, IBHV University of Copenhagen, Frederiksberg, Denmark, Department of Theoretical Chemistry, University of Vienna, Wien, Austria
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From Structure Prediction to Genomic Screens for Novel Non-Coding RNAs

Jan Gorodkin,
Ivo L. Hofacker

Published: August 4, 2011
https://doi.org/10.1371/journal.pcbi.1002100

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Citation & discussion missing

Posted by JPanek on 10 Aug 2011 at 12:32 GMT

Suboptimal structures have not yet been taken systematically into account in ncRNA gene finding methods. However, at least in some cases, they might be essential for the detection of functional RNAs.
http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002100#article1.body1.sec7.p7

A paper thoroughly dealing with the issue has been published ("The suboptimal structures find the optimal RNAs: homology search for bacterial non-coding RNAs using suboptimal RNA structures” by Pánek J, Krásny L, Bobek J, Jezková E, Korelusová J and Vohradsky J., Nucleic Acids Res. 2011 Apr;39(8):3418-26. Epub 2010 Dec 30.).

No competing interests declared.

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From Structure Prediction to Genomic Screens for Novel Non-Coding RNAs

From Structure Prediction to Genomic Screens for Novel Non-Coding RNAs

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Citation & discussion missing

Posted by JPanek on 10 Aug 2011 at 12:32 GMT