Research Article

A Probabilistic Model of Local Sequence Alignment That Simplifies Statistical Significance Estimation

  • Sean R. Eddy mail

    Affiliation: Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, United States of America

  • Published: May 30, 2008
  • DOI: 10.1371/journal.pcbi.1000069

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Publisher's Note: Correction to Equation

Posted by PLoS_CompBiol on 11 Jul 2008 at 14:35 GMT

The Forward score distribution is predicted to converge to an exponential with λ = log 2, with the approximation holding above some score threshold τ:

In the Results section, under the “Local Forward Scores Follow Exponential Tails with Constant λ” heading, the first equation was incorrect. The correct equation is:
P(F>t) \propto e^{-\lambda t - \tau)}, as seen here: