Advertisement
Research Article

A Probabilistic Model of Local Sequence Alignment That Simplifies Statistical Significance Estimation

  • Sean R. Eddy mail

    eddys@janelia.hhmi.org

    Affiliation: Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, United States of America

    X
  • Published: May 30, 2008
  • DOI: 10.1371/journal.pcbi.1000069

Reader Comments (1)

Post a new comment on this article

Publisher's Note: Correction to Equation

Posted by PLoS_CompBiol on 11 Jul 2008 at 14:35 GMT

The Forward score distribution is predicted to converge to an exponential with λ = log 2, with the approximation holding above some score threshold τ:
http://ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000069#article1.body1.sec2.sec6.p1

In the Results section, under the “Local Forward Scores Follow Exponential Tails with Constant λ” heading, the first equation was incorrect. The correct equation is:
P(F>t) \propto e^{-\lambda t - \tau)}, as seen here: http://www.ploscompbiol.org/corrections/pcbi.1000069.cn.pdf