About the Authors
- Kay Hamacher
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*To whom correspondence should be addressed. E-mail: hamacher_at_ctbp.ucsd .edu
Affiliations Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America , Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America
- Joanna Trylska
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Affiliations Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America , Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America , Interdisciplinary Centre for Mathematical and Computational Modelling, Warsaw University, Warsaw, Poland
- J. Andrew McCammon
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Affiliations Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America , Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America , Howard Hughes Medical Institute and Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
KH, JT, and JAM formulated the project. KH wrote the software, performed all the computations, and performed the sensitivity analysis. KH and JT analyzed the results. JT prepared the 30S subunit structure for computations and designed the computational validation experiments. KH, JT, and JAM wrote the paper.