About the Authors

Martin Meier-Schellersheim

To whom correspondence should be addressed. E-mail: rgermain@niaid.nih.gov (RNG, general correspondence); mms@niaid.nih.gov (MMS, specific correspondence about Simmune)

Affiliation Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Xuehua Xu

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Bethesda, Maryland, United States of America

Bastian Angermann

Affiliations Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America , Institute for Theoretical Physics, Faculty for Mathematics and Natural Sciences, University of Hamburg, Hamburg, Germany

Eric J Kunkel

Affiliation BioSeek, Inc., Burlingame, California, United States of America

Tian Jin

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Bethesda, Maryland, United States of America

Ronald N Germain

To whom correspondence should be addressed. E-mail: rgermain@niaid.nih.gov (RNG, general correspondence); mms@niaid.nih.gov (MMS, specific correspondence about Simmune)

Affiliation Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MMS, TJ, and RNG conceived and designed the experiments. XX and TJ performed the experiments. MMS, XX, and TJ analyzed the data. BA wrote the network browser software. EJK and RNG contributed to the improvement of the software. MMS wrote the software Simmune. MMS and RNG wrote the paper.