Computational Model Explains High Activity and Rapid Cycling of Rho GTPases within Protein Complexes

Open Access

Peer-reviewed

Research Article

About the Authors

Andrew B Goryachev

Contributed equally to this work with: Andrew B Goryachev, Alexandra V Pokhilko

*To whom correspondence should be addressed. E-mail: Andrew.Goryachev@ed.ac.uk

¤ Current address: Centre for Integrative Systems Biology, School of Biological Sciences, University of Edinburgh, United Kingdom

Affiliation Systems Biology Group, Bioinformatics Institute, Singapore, Singapore

Alexandra V Pokhilko

Contributed equally to this work with: Andrew B Goryachev, Alexandra V Pokhilko

¤ Current address: Centre for Integrative Systems Biology, School of Biological Sciences, University of Edinburgh, United Kingdom

Affiliation Systems Biology Group, Bioinformatics Institute, Singapore, Singapore

The authors have declared that no competing interests exist.

ABG and AVP conceived, designed, and performed the experiments; analyzed the data; and wrote the paper.

Guanosine triphosphatase
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Guanine nucleotide exchange factors
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Protein complexes
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GTPase signaling
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G-protein signaling
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Membrane protein complexes
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Nucleotides
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Yeast
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