About the Authors

Haiyuan Yu

Contributed equally to this work with: Haiyuan Yu, Philip M Kim

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America , Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America , Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Philip M Kim

Contributed equally to this work with: Haiyuan Yu, Philip M Kim

Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

Emmett Sprecher

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America , Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Valery Trifonov

Affiliation Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

Mark Gerstein

To whom correspondence should be addressed. E-mail: Mark.Gerstein@yale.edu

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America , Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America , Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

HY, PMK, and MG conceived and designed the experiments and wrote the paper. HY, PMK, and VT performed the experiments. HY, PMK, and ES analyzed the data. HY and MG contributed reagents/materials/analysis tools.