About the Authors

Matteo Barberis

Contributed equally to this work with: Matteo Barberis, Edda Klipp

Affiliations Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy , Max-Planck Institute for Molecular Genetics, Computational Systems Biology, Berlin, Germany

Edda Klipp

Contributed equally to this work with: Matteo Barberis, Edda Klipp

To whom correspondence should be addressed. E-mail: klipp@molgen.mpg.de (EK); lilia.alberghina@unimib.it (LA)

Affiliation Max-Planck Institute for Molecular Genetics, Computational Systems Biology, Berlin, Germany

Marco Vanoni

Affiliation Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

Lilia Alberghina

To whom correspondence should be addressed. E-mail: klipp@molgen.mpg.de (EK); lilia.alberghina@unimib.it (LA)

Affiliation Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MB data-mined the literature, designed the structure of the mathematical model, and performed the simulations. EK provided modeling experience and mathematical model implementation. LA data-mined the literature and conceived the structure of the model. MB, EK, and LA planned simulation experiments. MB, MV, and LA evaluated biological significance. MB EK, MV, and LA wrote the paper.