About the Authors

Adam M Phillippy

To whom correspondence should be addressed. E-mail: amp@umiacs.umd.edu

Affiliation Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, United States of America

Jacquline A Mason

Affiliation Canon U.S. Life Sciences, Rockville, Maryland, United States of America

Kunmi Ayanbule

Affiliation Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, United States of America

Daniel D Sommer

Affiliation Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, United States of America

Elisa Taviani

Affiliation Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland, United States of America

Anwar Huq

Affiliation Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland, United States of America

Rita R Colwell

Affiliations Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, United States of America , Canon U.S. Life Sciences, Rockville, Maryland, United States of America

Ivor T Knight

Affiliations Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, United States of America , Canon U.S. Life Sciences, Rockville, Maryland, United States of America

Steven L Salzberg

Affiliation Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AMP, KA, and SLS designed Insignia. DDS tested Insignia and managed the computing cluster. JAM and ITK designed and performed the validation experiments. ET, AH, and RRC determined the validation strains and contributed the DNA samples. AMP, JAM, ITK, and SLS prepared the manuscript.