About the Authors

Sven Zenker

Affiliations Center for Inflammation and Regenerative Modeling, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America , Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America , Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Jonathan Rubin

Affiliation Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Gilles Clermont

To whom correspondence should be addressed. E-mail: cler@pitt.edu

Affiliations Center for Inflammation and Regenerative Modeling, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America , Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SZ and GC conceived and designed the experiments. SZ and JR performed model development. SZ performed the experiments. SZ and JR analyzed the data and performed mathematical analysis. SZ and GC contributed reagents/materials/analysis tools. SZ and JR wrote the paper.