About the Authors

Niko Beerenwinkel

To whom correspondence should be addressed. E-mail: niko.beerenwinkel@bsse.ethz.ch

¤ Current address: Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

Affiliation Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America

Tibor Antal

Affiliation Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America

David Dingli

Affiliation Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America

Arne Traulsen

Affiliation Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America

Kenneth W Kinzler

Affiliation Ludwig Center, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America

Victor E Velculescu

Affiliation Ludwig Center, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America

Bert Vogelstein

Affiliations Ludwig Center, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America , Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, Maryland, United States of America

Martin A Nowak

Affiliation Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KWK, VEV, and BV designed and performed experiments that formed the basis for the evaluation; NB, TA, DD, AT, and MAN developed the mathematical model; and NB, TA, DD, BV, and MAN wrote the paper.