Predicting Protein Function with Hierarchical Phylogenetic Profiles: The Gene3D Phylo-Tuner Method Applied to Eukaryotic Genomes

Juan A. G Ranea; Corin Yeats; Alastair Grant; Christine A Orengo

doi:10.1371/journal.pcbi.0030237

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Open Access

Peer-reviewed

Research Article

Predicting Protein Function with Hierarchical Phylogenetic Profiles: The Gene3D Phylo-Tuner Method Applied to Eukaryotic Genomes

Juan A. G Ranea ,

*To whom correspondence should be addressed. E-mail: ranea@biochem.ucl.ac.uk

Affiliation Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
⨯
Corin Yeats,

Affiliation Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
⨯
Alastair Grant,

Affiliation Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
⨯
Christine A Orengo

Affiliation Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
⨯

Predicting Protein Function with Hierarchical Phylogenetic Profiles: The Gene3D Phylo-Tuner Method Applied to Eukaryotic Genomes

Juan A. G Ranea,
Corin Yeats,
Alastair Grant,
Christine A Orengo

Published: November 30, 2007
https://doi.org/10.1371/journal.pcbi.0030237

About the Authors

Juan A. G Ranea

*To whom correspondence should be addressed. E-mail: ranea@biochem.ucl.ac.uk

Affiliation Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom

Corin Yeats

Affiliation Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom

Alastair Grant

Affiliation Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom

Christine A Orengo

Affiliation Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All authors conceived and designed the experiments. JAGR and CY performed the experiments. JAGR, CY, and CAO analyzed the data and wrote the paper. JAGR, CY, and AG contributed reagents/materials/analysis tools.

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Eukaryota
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Protein domains
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Genomics
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Phylogenetics
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Functional genomics
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Gene ontologies
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Genome annotation
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Human genomics
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