Co-Regulation of Metabolic Genes Is Better Explained by Flux Coupling Than by Network Distance

Richard A Notebaart; Bas Teusink; Roland J Siezen; Balázs Papp

doi:10.1371/journal.pcbi.0040026

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Open Access

Peer-reviewed

Research Article

Co-Regulation of Metabolic Genes Is Better Explained by Flux Coupling Than by Network Distance

Richard A Notebaart,

Affiliation Center for Molecular and Biomolecular Informatics (NCMLS), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
⨯
Bas Teusink,

Affiliations Center for Molecular and Biomolecular Informatics (NCMLS), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands , NIZO Food Research BV, Ede, The Netherlands , TI Food and Nutrition (WCFS), Wageningen, The Netherlands
⨯
Roland J Siezen,

Affiliations Center for Molecular and Biomolecular Informatics (NCMLS), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands , NIZO Food Research BV, Ede, The Netherlands , TI Food and Nutrition (WCFS), Wageningen, The Netherlands
⨯
Balázs Papp

*To whom correspondence should be addressed. E-mail: pappb@brc.hu

Affiliations Institute of Biochemistry, Biological Research Center, Szeged, Hungary , Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯

Co-Regulation of Metabolic Genes Is Better Explained by Flux Coupling Than by Network Distance

Richard A Notebaart,
Bas Teusink,
Roland J Siezen,
Balázs Papp

Published: January 25, 2008
https://doi.org/10.1371/journal.pcbi.0040026

About the Authors

Richard A Notebaart

Affiliation Center for Molecular and Biomolecular Informatics (NCMLS), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

Bas Teusink

Affiliations Center for Molecular and Biomolecular Informatics (NCMLS), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands , NIZO Food Research BV, Ede, The Netherlands , TI Food and Nutrition (WCFS), Wageningen, The Netherlands

Roland J Siezen

Balázs Papp

*To whom correspondence should be addressed. E-mail: pappb@brc.hu

Affiliations Institute of Biochemistry, Biological Research Center, Szeged, Hungary , Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RAN and BP conceived and designed the experiments, performed the experiments, analyzed the data, and wrote the paper. BT contributed to method development. BT and RJS contributed by revising the manuscript.

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Genetic networks
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Metabolic networks
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Operons
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Gene regulation
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Enzyme metabolism
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Transcriptional control
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Functional genomics
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Saccharomyces cerevisiae
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