About the Authors

Stephen A. Ramsey

sramsey@systemsbiology.org (SR); aderem@systemsbiology.org (AA); ishmulevich@systemsbiology.org (IS)

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Sandy L. Klemm

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Daniel E. Zak

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Kathleen A. Kennedy

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Vesteinn Thorsson

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Bin Li

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Mark Gilchrist

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Elizabeth S. Gold

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Carrie D. Johnson

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Vladimir Litvak

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Garnet Navarro

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Jared C. Roach

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Carrie M. Rosenberger

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Alistair G. Rust

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Natalya Yudkovsky

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Alan Aderem

sramsey@systemsbiology.org (SR); aderem@systemsbiology.org (AA); ishmulevich@systemsbiology.org (IS)

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Ilya Shmulevich

sramsey@systemsbiology.org (SR); aderem@systemsbiology.org (AA); ishmulevich@systemsbiology.org (IS)

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SR DZ KK. Performed the experiments: DZ KK MG EG CJ VL GN CR NY. Analyzed the data: SR BL. Contributed reagents/materials/analysis tools: SR VT BL JR AR. Wrote the paper: SR. Helped develop the statistical test used in this work: SK. Carried out qPCR and microarray expression experiments: DZ. Generated the SMAD/TGIF protein interaction network: VT. Wrote the ChIP-on-chip data processing program and processed the ChIP-on-chip data: BL. Developed a hand-curated list of murine cytokines and chemokines: NY. Supervised the project and provided advice on the writing of the manuscript: AA IS.