About the Authors

Patrycja Vasilyev Missiuro

Affiliations Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Kesheng Liu

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Lihua Zou

Affiliation Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Brian C. Ross

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Guoyan Zhao

Affiliation Department of Genetics, Washington University, St. Louis, Missouri, United States of America

Jun S. Liu

Affiliation Department of Statistics, Harvard University, Cambridge, Massachusetts, United States of America

Hui Ge

hge@wi.mit.edu

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PVM LZ BCR JSL HG. Performed the experiments: KL. Analyzed the data: PVM GZ HG. Contributed reagents/materials/analysis tools: PVM. Wrote the paper: PVM HG. Responsible for all computational work, designed and implemented an independent version of algorithm that is introduced in the paper: PVM. Responsible for all experimental work that is presented in the paper: KL. Originally discussed the idea, designed another independent version of the algorithm (not used in the paper): LZ BCR. Provided computational analysis on muscle-specific motif modules that is used in the paper: GZ.