About the Authors
- Manash S. Chatterjee
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Affiliation Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania. Philadelphia, Pennslyvania, United States of America
- William S. Denney
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Affiliation Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania. Philadelphia, Pennslyvania, United States of America
- Huiyan Jing
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Affiliation Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania. Philadelphia, Pennslyvania, United States of America
- Scott L. Diamond
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* E-mail: sld@seas.upenn.edu
Affiliation Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania. Philadelphia, Pennslyvania, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Supervised all research: SLD. Constructed the platelet plasma model and performed the well-plate experiments in Figures 3–8: MSC. Performed the sensitivity analysis in Figure S1 in Text S1: MSC. Performed the TAT ELISAs to validate the fluorogenic assay (Figures 3C, D): MSC HJ. Wrote the paper with contributions from all authors: MSC. Performed the well-plate experiments titrating active proteases into blood (Figure 9): WSD.