Understanding the Origins of Bacterial Resistance to Aminoglycosides through Molecular Dynamics Mutational Study of the Ribosomal A-Site

Julia Romanowska; J. Andrew McCammon; Joanna Trylska

doi:10.1371/journal.pcbi.1002099

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Open Access

Peer-reviewed

Research Article

Understanding the Origins of Bacterial Resistance to Aminoglycosides through Molecular Dynamics Mutational Study of the Ribosomal A-Site

Julia Romanowska ,

* E-mail: jrom@icm.edu.pl

Affiliations Department of Biophysics, Faculty of Physics, University of Warsaw, Warsaw Poland, Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland
⨯
J. Andrew McCammon,

Affiliations Department of Chemistry and Biochemistry, University of California, San Diego, California, United States of America, Center for Theoretical Biological Physics, University of California, San Diego, California, United States of America, Department of Pharmacology, University of California, San Diego, California, United States of America, Howard Hughes Medical Institute, University of California, San Diego, California, United States of America
⨯
Joanna Trylska

Affiliation Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland
⨯

Understanding the Origins of Bacterial Resistance to Aminoglycosides through Molecular Dynamics Mutational Study of the Ribosomal A-Site

Julia Romanowska,
J. Andrew McCammon,
Joanna Trylska

Published: July 21, 2011
https://doi.org/10.1371/journal.pcbi.1002099

About the Authors

Julia Romanowska

* E-mail: jrom@icm.edu.pl

Affiliations Department of Biophysics, Faculty of Physics, University of Warsaw, Warsaw Poland, Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland

J. Andrew McCammon

Affiliations Department of Chemistry and Biochemistry, University of California, San Diego, California, United States of America, Center for Theoretical Biological Physics, University of California, San Diego, California, United States of America, Department of Pharmacology, University of California, San Diego, California, United States of America, Howard Hughes Medical Institute, University of California, San Diego, California, United States of America

Joanna Trylska

Affiliation Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JR JT. Performed the experiments: JR. Analyzed the data: JR JT. Wrote the paper: JR JAM JT.

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Biochemical simulations
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RNA structure
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Adenine
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Substitution mutation
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Antibiotics
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