Reversible and Noisy Progression towards a Commitment Point Enables Adaptable and Reliable Cellular Decision-Making

Anna Kuchina; Lorena Espinar; Jordi Garcia-Ojalvo; Gürol M. Süel

doi:10.1371/journal.pcbi.1002273

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Peer-reviewed

Research Article

Reversible and Noisy Progression towards a Commitment Point Enables Adaptable and Reliable Cellular Decision-Making

Anna Kuchina ,

Contributed equally to this work with: Anna Kuchina, Lorena Espinar

Affiliations Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
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Lorena Espinar ,

Contributed equally to this work with: Anna Kuchina, Lorena Espinar

Affiliation Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Terrassa, Spain
⨯
Jordi Garcia-Ojalvo,

Affiliation Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Terrassa, Spain
⨯
Gürol M. Süel

* E-mail: gurol.suel@utsouthwestern.edu

Affiliations Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯

Reversible and Noisy Progression towards a Commitment Point Enables Adaptable and Reliable Cellular Decision-Making

Anna Kuchina,
Lorena Espinar,
Jordi Garcia-Ojalvo,
Gürol M. Süel

Published: November 10, 2011
https://doi.org/10.1371/journal.pcbi.1002273

About the Authors

Anna Kuchina

Contributed equally to this work with: Anna Kuchina, Lorena Espinar

Affiliations Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Lorena Espinar

Contributed equally to this work with: Anna Kuchina, Lorena Espinar

Affiliation Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Terrassa, Spain

Jordi Garcia-Ojalvo

Affiliation Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Terrassa, Spain

Gürol M. Süel

* E-mail: gurol.suel@utsouthwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AK LE JGO GMS. Performed the experiments: AK LE. Analyzed the data: AK LE JGO GMS. Contributed reagents/materials/analysis tools: AK LE JGO GMS. Wrote the paper: AK LE JGO GMS.

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Bacterial sporulation
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Bacillus subtilis
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Decision making
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Bacterial spores
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Cell differentiation
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Fungal spores
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Gene expression
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Multipotency
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