Depression-Biased Reverse Plasticity Rule Is Required for Stable Learning at Top-Down Connections

Kendra S. Burbank; Gabriel Kreiman

doi:10.1371/journal.pcbi.1002393

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Open Access

Peer-reviewed

Research Article

Depression-Biased Reverse Plasticity Rule Is Required for Stable Learning at Top-Down Connections

Kendra S. Burbank,

Affiliation Department of Neurology and Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
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Gabriel Kreiman

* E-mail: Gabriel.kreiman@tch.harvard.edu

Affiliations Department of Neurology and Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America, Swartz Center for Theoretical Neuroscience, Harvard University, Cambridge, Massachusetts, United States of America
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Depression-Biased Reverse Plasticity Rule Is Required for Stable Learning at Top-Down Connections

Kendra S. Burbank,
Gabriel Kreiman

Published: March 1, 2012
https://doi.org/10.1371/journal.pcbi.1002393

About the Authors

Kendra S. Burbank

Affiliation Department of Neurology and Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

Gabriel Kreiman

* E-mail: Gabriel.kreiman@tch.harvard.edu

Affiliations Department of Neurology and Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America, Swartz Center for Theoretical Neuroscience, Harvard University, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KSB GK. Performed the experiments: KSB. Analyzed the data: KSB GK. Wrote the paper: KSB GK.

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Neurons
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Synapses
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Action potentials
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Synaptic plasticity
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Neuronal plasticity
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Depression
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