Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation

Laurent F. Thomas; Pål Sætrom

doi:10.1371/journal.pcbi.1002621

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Open Access

Peer-reviewed

Research Article

Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation

Laurent F. Thomas,

Affiliations Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway, Interagon AS, Laboratoriesenteret, Trondheim, Norway
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Pål Sætrom

* E-mail: pal.satrom@ntnu.no

Affiliations Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway, Interagon AS, Laboratoriesenteret, Trondheim, Norway, Department of Computer and Information Science, Norwegian University of Science and Technology, Trondheim, Norway
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Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation

Laurent F. Thomas,
Pål Sætrom

Published: August 16, 2012
https://doi.org/10.1371/journal.pcbi.1002621

About the Authors

Laurent F. Thomas

Affiliations Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway, Interagon AS, Laboratoriesenteret, Trondheim, Norway

Pål Sætrom

* E-mail: pal.satrom@ntnu.no

Affiliations Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway, Interagon AS, Laboratoriesenteret, Trondheim, Norway, Department of Computer and Information Science, Norwegian University of Science and Technology, Trondheim, Norway

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LFT PS. Performed the experiments: LFT. Analyzed the data: LFT PS. Contributed reagents/materials/analysis tools: LFT. Wrote the paper: LFT PS.

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Single nucleotide polymorphisms
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MicroRNAs
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Polyadenylation
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Gene expression
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Homozygosity
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Alleles
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Variant genotypes
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Genome-wide association studies
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