About the Authors

Libin Rong

Contributed equally to this work with: Libin Rong, Jeremie Guedj, Harel Dahari

Affiliation Department of Mathematics and Statistics and Center for Biomedical Research, Oakland University, Rochester, Michigan, United States of America

Jeremie Guedj

Contributed equally to this work with: Libin Rong, Jeremie Guedj, Harel Dahari

Affiliations Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, University Paris Diderot, Sorbonne Paris Cite, 75018 Paris, France, INSERM, UMR 738, 75018 Paris, France

Harel Dahari

Contributed equally to this work with: Libin Rong, Jeremie Guedj, Harel Dahari

Affiliations Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine, Loyola University Chicago, Chicago, Illinois, United States of America

Daniel J. Coffield Jr

Affiliation University of Michigan-Flint, Mathematics Department, Flint, Michigan, United States of America

Micha Levi

Current address: Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, United States of America.

Affiliation Clinical Pharmacology, Pharma Research and Early Development, Roche, Nutley, New Jersey, United States of America

Patrick Smith

Affiliation Clinical Pharmacology, Pharma Research and Early Development, Roche, Nutley, New Jersey, United States of America

Alan S. Perelson

asp@lanl.gov

Affiliation Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LR JG HD ASP. Performed the experiments: LR JG HD ASP. Analyzed the data: LR JG HD ASP. Contributed reagents/materials/analysis tools: DJC ML PS. Wrote the paper: LR JG PS ASP.