On the Role of Aggregation Prone Regions in Protein Evolution, Stability, and Enzymatic Catalysis: Insights from Diverse Analyses

Patrick M. Buck; Sandeep Kumar; Satish K. Singh

doi:10.1371/journal.pcbi.1003291

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Open Access

Peer-reviewed

Research Article

On the Role of Aggregation Prone Regions in Protein Evolution, Stability, and Enzymatic Catalysis: Insights from Diverse Analyses

Patrick M. Buck ,

¶These authors contributed equally towards the calculations: Patrick M. Buck, Sandeep Kumar

Affiliation Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri, United States of America
⨯
Sandeep Kumar ,

* E-mail: Sandeep.Kumar@Pfizer.com

¶These authors contributed equally towards the calculations: Patrick M. Buck, Sandeep Kumar

Affiliation Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri, United States of America
⨯
Satish K. Singh

Affiliation Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri, United States of America
⨯

On the Role of Aggregation Prone Regions in Protein Evolution, Stability, and Enzymatic Catalysis: Insights from Diverse Analyses

Patrick M. Buck,
Sandeep Kumar,
Satish K. Singh

Published: October 17, 2013
https://doi.org/10.1371/journal.pcbi.1003291

About the Authors

Patrick M. Buck

¶These authors contributed equally towards the calculations: Patrick M. Buck, Sandeep Kumar

Affiliation Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri, United States of America

Sandeep Kumar

* E-mail: Sandeep.Kumar@Pfizer.com

¶These authors contributed equally towards the calculations: Patrick M. Buck, Sandeep Kumar

Affiliation Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri, United States of America

Satish K. Singh

Affiliation Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri, United States of America

Competing Interests

PMB, SK and SKS are paid employees of Pfizer, Inc.

Author Contributions

Conceived and designed the experiments: PMB SK. Performed the experiments: PMB SK. Analyzed the data: PMB SK. Contributed reagents/materials/analysis tools: PMB SK SKS. Wrote the paper: PMB SK.

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Protein sequencing
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Protein structure
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Intrinsically disordered proteins
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Solubility
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Protein folding
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Enzymes
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Lysozyme
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Sequence alignment
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