About the Authors

Takeshi Hase

Contributed equally to this work with: Takeshi Hase, Samik Ghosh

Affiliations The Systems Biology Institute, Shirokanedai, Minato, Tokyo, Japan, Laboratory of Disease Systems Modeling, Center for Integrative Medical Sciences, RIKEN, Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, Japan

Samik Ghosh

Contributed equally to this work with: Takeshi Hase, Samik Ghosh

ghosh@sbi.jp (SG); kitano@sbi.jp (HK)

Affiliations The Systems Biology Institute, Shirokanedai, Minato, Tokyo, Japan, Laboratory of Disease Systems Modeling, Center for Integrative Medical Sciences, RIKEN, Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, Japan

Ryota Yamanaka

Affiliations The Systems Biology Institute, Shirokanedai, Minato, Tokyo, Japan, Department of Genome Science, RCAST, The University of Tokyo, Komaba, Meguro, Tokyo, Japan

Hiroaki Kitano

ghosh@sbi.jp (SG); kitano@sbi.jp (HK)

Affiliations The Systems Biology Institute, Shirokanedai, Minato, Tokyo, Japan, Laboratory of Disease Systems Modeling, Center for Integrative Medical Sciences, RIKEN, Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, Japan, Sony Computer Science Laboratories, Inc., Higashigotanda, Shinagawa, Tokyo, Japan, Okinawa Institute of Science and Technology, Onna, Onna-son, Kunigami, Okinawa, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TH SG HK. Performed the experiments: TH SG. Analyzed the data: TH SG. Contributed reagents/materials/analysis tools: TH SG RY HK. Wrote the paper: TH SG RY HK.