An Evolution-Based Approach to De Novo Protein Design and Case Study on Mycobacterium tuberculosis

• Pralay Mitra ,

  Contributed equally to this work with: Pralay Mitra, David Shultis

  Affiliation Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

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• David Shultis ,

  Contributed equally to this work with: Pralay Mitra, David Shultis

  Affiliation Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Jeffrey R. Brender,

  Affiliation Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Jeff Czajka,

  Affiliation Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

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• David Marsh,

  Affiliation Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Felicia Gray,

  Affiliation Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Tomasz Cierpicki,

  Affiliation Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Yang Zhang

  * E-mail: zhng@umich.edu

  Affiliations Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America

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