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Dynamic Control of Selectivity in the Ubiquitination Pathway Revealed by an ASP to GLU Substitution in an Intra-Molecular Salt-Bridge Network

  • Sjoerd J. L. van Wijk ,

    Contributed equally to this work with: Sjoerd J. L. van Wijk, Adrien S. J. Melquiond

    Current address: Institute of Biochemistry II and Buchman Institute for Molecular Life Sciences (FMLS), Goethe University School of Medicine, University Hospital, Frankfurt am Main, Germany.

    Affiliation Department of Molecular Cancer Research, Division of Biomedical Genetics and Netherlands Proteomics Center, University Medical Center Utrecht, Utrecht, The Netherlands

  • Adrien S. J. Melquiond ,

    Contributed equally to this work with: Sjoerd J. L. van Wijk, Adrien S. J. Melquiond

    Affiliation Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

  • Sjoerd J. de Vries,

    Current address: Biomolecular Dynamics, Department of Physics T38, Technical University München, Garching, Germany.

    Affiliation Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

  • H. Th. Marc Timmers,

    Affiliation Department of Molecular Cancer Research, Division of Biomedical Genetics and Netherlands Proteomics Center, University Medical Center Utrecht, Utrecht, The Netherlands

  • Alexandre M. J. J. Bonvin

    A.M.J.J.Bonvin@uu.nl

    Affiliation Computational Structural Biology Group, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands

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