Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

Open Access

Peer-reviewed

Research Article

Himadri Mukhopadhyay,

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, Oxfordshire, United Kingdom
⨯
Shaun-Paul Cordoba,

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, Oxfordshire, United Kingdom
⨯
Philip K. Maini,

Affiliation Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, Oxfordshire, United Kingdom
⨯
P. Anton van der Merwe ,

* E-mail: anton.vandermerwe@path.ox.ac.uk (PAvdM); omer.dushek@path.ox.ac.uk (OD)

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, Oxfordshire, United Kingdom
⨯
Omer Dushek

* E-mail: anton.vandermerwe@path.ox.ac.uk (PAvdM); omer.dushek@path.ox.ac.uk (OD)

Affiliations Sir William Dunn School of Pathology, University of Oxford, Oxford, Oxfordshire, United Kingdom, Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, Oxfordshire, United Kingdom
⨯

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Phosphorylation
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T cell receptors
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TCR signaling cascade
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Phosphatases
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T cells
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Antigens
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Tyrosine kinases
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Immune receptors
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