Polymorphisms in the F8 Gene and MHC-II Variants as Risk Factors for the Development of Inhibitory Anti-Factor VIII Antibodies during the Treatment of Hemophilia A: A Computational Assessment

• Gouri Shankar Pandey ,

  ¶GSP and CY contributed equally to this work; the names are listed alphabetically.

  Affiliation Laboratory of Hemostasis, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America

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• Chen Yanover ,

  Current address: Machine Learning Group, IBM Research Laboratory, Haifa, Israel.

  ¶GSP and CY contributed equally to this work; the names are listed alphabetically.

  Affiliation Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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• Tom E. Howard,

  Affiliation Department of Pathology and Laboratory Medicine, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America

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• Zuben E. Sauna

  * E-mail: zuben.sauna@fda.hhs.gov

  Affiliation Laboratory of Hemostasis, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America

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