About the Authors

Simeone Marino

Affiliation Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Dhruv Sud

Affiliations Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America , Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan, United States of America

Hillarie Plessner

Affiliation Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Philana Ling Lin

Affiliation Department of Pediatrics, Division of Pediatric Infectious Disease, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

John Chan

Affiliations Department of Medicine, Albert Einstein College of Medicine, New York, New York, United States of America , Department of Microbiology, Albert Einstein College of Medicine, New York, New York, United States of America , Department of Immunology, Albert Einstein College of Medicine, New York, New York, United States of America

JoAnne L Flynn

Affiliation Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Denise E Kirschner

To whom correspondence should be addressed. E-mail: kirschne@umich.edu

Affiliations Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America , Department of Medicine, Albert Einstein College of Medicine, New York, New York, United States of America

Competing Interests

Our collaborator on this project, Joanne Flynn from the University of Pittsburgh, has received funding in the form of a Research Grant from Amgen, the company that makes Etanercept. Although this does not directly support the research in this manuscript, the Research Grant does fund studies on TNF and TB.

Author Contributions

SM, JLF, and DEK conceived and designed the experiments and wrote the paper. SM and PLL performed the experiments. SM, HP, PLL, JC, JLF, and DEK analyzed the data. SM, DS, HP, and PLL contributed reagents/materials/analysis tools.